Bills vs Rams: Week 1 NFL picks as Buffalo invades Los Angeles

The Los Angeles Rams are 2.5-point underdogs at home in the NFL season opener against the Buffalo Bills and that’s after a the Rams opened as favorites, according to DraftKings Sportsbook. Bettors feel strongly that the Bills are about to have their best season since the early 90’s but the home team in Los Angeles doesn’t need to go back 30 years to find the last time they were in the Super Bowl.

They only need go back to February.

We’ve partnered with Tallysight to make our picks every week this season and you should join in on the action to compare your predictions against the experts at SB Nation. And you can start with tonight’s game between the Rams and Bills.

In 2020, the Rams lost in Buffalo in a thriller, 35-32. If that same score happens on Thursday night, then the Bills will just barely cover. However, I think that the Rams will go to 6-0 under Sean McVay in Week 1 games and start off with a winning record once again.

What’s your final score prediction for Thursday Night Football?