QB Drew Brees
This one is a gimme. Brees is a first ballot Hall of Famer who can still sling it at 37 years old. The Rams secondary lost Troy Hill this week... the secondary is going to have it's work cut out to keep the Saints from running up the score.
WR Brandin Cooks
Enter Brees' favorite target. Cooks may have yielded some of his targets to rookie Michael Thomas (the not-Rams one), but is still leading the Saints in most major receiving categories. Get to work Tru.
DT Nick Fairley
Rams fans know from Fairley's brief stint on in St. Louis that he is one slippery mofo. His effort concerns continue to plague him as he occasionally takes plays off, but he has the raw ability to wreak havoc on any OL - especially one playing as poorly as the Rams is.
If the Rams want to get Todd Gurley going in what is going to be an extremely hostile environment for Jared Goff, they'd be wise to make Fairley a priority with blocking schemes.
DE Cameron Jordan
Meet the Saints best defender. Jordan has been on a tear over the past few months and will provide a struggling Greg Robinson with quite the test. Someone start praying that G-Rob doesn't get Goff killed.
Better yet.... who can make a voodoo doll of Jordan?
SS Kenny Vaccaro
As QBKlass noted in his preview, the Saints CBs do a good job defending outside the hash marks and down the sideline. However, they're vulnerable in the middle of the field. The Rams slot WRs (Tavon Austin, Pharoh Cooper) are diminutive in stature and haven't shown the ability to stick in there and take a hit for the tough completions. Vacarro's presence is going to make Goff's first road start even more daunting.