Game Date/Time and Location: Sunday, Dec. 1, 4:05 p.m. ET at Candlestick Park, San Francisco, Calif.
TV schedule and distribution map: Fox; The506.com
Live coverage and updates:
Radio schedule: St. Louis: 101 ESPN (101.1 FM WXOS); San Francisco: KNBR 680/1050 AM and KSAN 107.7 FM
More on the matchup: San Francisco won convincingly when these teams last met in late September. Frank Gore ran for over 150 total yards, while Anquan Boldin and Vernon Davis each caught touchdowns in a 35-11 win. St. Louis has changed offensively since that point, losing Sam Bradford to injury but galvanizing as an overall team. The passing game has suffered, but running the ball has become a more reliable option while rookie Tavon Austin is starting to make an impact. These factors, paired with both teams' excellent defensive line play, are reasons to watch them on Sunday.