The only players who will miss the game this week are WR Danario Alexander and SS James Butler.
That's too bad on Alexander because the Rams could really use that added dimension to their passing game. San Francisco struggles against the deep pass; Alexander gave the Rams a player who could work threaten teams deep, at least on a few routes like he did against San Diego.
Teams have been successful passing on the 49ers. Sam Bradford will once again have to make the air game work with the receivers he has, though the Rams offense has been much better about mixing up designed plays that take advantage of individual player strengths. Nevertheless, they'll have to find guys who can matchup well with a tough group of linebackers led by Patrick Willis and preferably make enough passes behind them to keep the defense guessing.
TE Fendi Onobun practiced today. It remains to be seen whether or not he'll be active this week. I'd bet against it. Hopefully, now that he's healthy, the Rams can work him into a few plays here and there in the weeks ahead, if for other reason than to beef up their receiving options by quantity.